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Because keloid and hypertrophic scars often require multiple steroid injections over a period of weeks or months, there is increased risk for both immediate and delayed reactions.1–4 This paper describes the use of ketoconazole to treat keloid scars.1,4 Methods Methods We performed a double-blind, placebo-controlled trial with 80 patients (80 women, 35 men, mean age, 50 years) undergoing treatment, of moderate- to severe hypertrophic scars (the other patients did not report an incident hypertrophic scar). We treated patients in the first phase of isotretinoin with 6 milligrams intravenously or 6 drops on ice.5,6 All patients began treatment with topical lidocaine cream, and then the patients were instructed to get a weekly application of keloid extract, as directed by the treating physician. Patients could receive multiple injections in up to 8 weeks. Patients received weekly injections of the keloid extract at 1 milligram in a single-dose vial, with the use of the oral vials (Figure 1). It should be understood that we were following an oral regimen based on the use of ketoconazole, not the combination of ketoconazole and the cream. The patients completed the study within 3 months. Informed consent was obtained from all patients. Details about the study design are provided in the Supplementary Data (in the online issue). Briefly, the first dose of isotretinoin was 20 mg twice a day. The second dose was 10 mg twice a day. The third and fourth doses were given on days 4 and 6, respectively. A second 1-year follow-up was not attempted because of the severity of the scarring. Figure 1 View largeDownload slide Tabs showing the composition of keloid with the keloid extract. Figure 1 View largeDownload slide Tabs showing the composition of keloid with the keloid extract. Keloid Treatment Inclusion criteria were as follows: patients who had moderate-to-severe hypertrophic scarring on the side of the face or between the eyebrows that had not previously been treated with isotretinoin (n = 18) or a previous steroid (n = 14). Patients with mild to moderate signs of keloid development or no keloid were included. Exclusion criteria were as follows: patients with the following conditions (mean age, 28 years): hypertrophic scarring on other site, the use of oral corticosteroids, or a history of nephrology, radiation therapy, or immunosuppressant treatments; a family history of severe Related Article: